{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:49:41Z","timestamp":1791517781892,"version":"4.3.4"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,2,2]]},"abstract":"<jats:p>\n                    Task2 K\n                    <jats:sup>+<\/jats:sup>\n                    channel expression in the central nervous system is surprisingly restricted to a few brainstem nuclei, including the retrotrapezoid (RTN) region. All Task2-positive RTN neurons were lost in mice bearing a Phox2b mutation that causes the human congenital central hypoventilation syndrome. In plethysmography,\n                    <jats:italic>\n                      Task2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice showed disturbed chemosensory function with hypersensitivity to low CO\n                    <jats:sub>2<\/jats:sub>\n                    concentrations, leading to hyperventilation. Task2 probably is needed to stabilize the membrane potential of chemoreceptive cells. In addition,\n                    <jats:italic>\n                      Task2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice lost the long-term hypoxia-induced respiratory decrease whereas the acute carotid-body-mediated increase was maintained. The lack of anoxia-induced respiratory depression in the isolated brainstem\u2013spinal cord preparation suggested a central origin of the phenotype. Task2 activation by reactive oxygen species generated during hypoxia could silence RTN neurons, thus contributing to respiratory depression. These data identify Task2 as a determinant of central O\n                    <jats:sub>2<\/jats:sub>\n                    chemoreception and demonstrate that this phenomenon is due to the activity of a small number of neurons located at the ventral medullary surface.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0910059107","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T23:53:28Z","timestamp":1263945208000},"page":"2325-2330","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":158,"title":["Task2 potassium channels set central respiratory CO\n                    <sub>2<\/sub>\n                    and O\n                    <sub>2<\/sub>\n                    sensitivity"],"prefix":"10.1073","volume":"107","author":[{"given":"Christian","family":"Gestreau","sequence":"first","affiliation":[{"name":"Department of Neurovegetative Physiology, Centre National de la Recherche Scientifique, 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