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Hsp90 inhibitors induce the death of established, EBV-transformed lymphoblastoid cell lines at doses nontoxic to normal cells, and this effect is substantially reversed when lymphoblastoid cell lines are stably infected with a retrovirus expressing a functional EBNA1 mutant lacking the Gly-Ala repeats. Hsp90 inhibitors prevent EBV transformation of primary B cells, and strongly inhibit the growth of EBV-induced lymphoproliferative disease in SCID mice. These results suggest that Hsp90 inhibitors may be particularly effective for treating EBV-induced diseases requiring the continued presence of the viral genome.<\/jats:p>","DOI":"10.1073\/pnas.0910717107","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T23:49:26Z","timestamp":1264549766000},"page":"3146-3151","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism"],"prefix":"10.1073","volume":"107","author":[{"given":"Xiaoping","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Barlow","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Ma","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy R.","family":"Hagemeier","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Duellman","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Tellam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Clive Berghofer Cancer Research Centre, Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Clive Berghofer Cancer Research Centre, Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon C.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Departments of aOncology and"},{"name":"Medicine, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_3_3_1_2","unstructured":"E Kieff AB Richinson Epstein-Barr virus and its replication. 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