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In contrast, we demonstrate VEGF receptor 2 (VEGFR2) is primarily expressed in nonvascular photoreceptors and ganglion cells. Moreover, blockade of VEGFR1 but not VEGFR2 significantly restores pericyte saturation in mature retinal vessels. Our findings link VEGF and PlGF to cancer-associated retinopathy, reveal the molecular mechanisms of VEGFR1 ligand-mediated retinopathy, and define VEGFR1 as an important target of antiangiogenic therapy for treatment of retinopathy.<\/jats:p>","DOI":"10.1073\/pnas.0911661107","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T21:09:29Z","timestamp":1261516169000},"page":"856-861","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":102,"title":["VEGFR1\u2013mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy"],"prefix":"10.1073","volume":"107","author":[{"given":"Renhai","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Hedlund","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaodong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Tritsaris","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Center for Healthy Aging, Panum Institute, University of Copenhagen, Copenhagen 2200N, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tondelli","sequence":"additional","affiliation":[{"name":"Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, 20090 Segrate, Italy;"},{"name":"Istituto Clinico Humanitas, 20089 Milano, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Lucchini","sequence":"additional","affiliation":[{"name":"Centro Ricerche Biotecnologiche and Istituto di Microbiologia, Universita\u2019 Cattolica del Sacro Cuore, 26100 Cremona, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Zhu","sequence":"additional","affiliation":[{"name":"ImClone Systems Incorporated, New York, NY 10014"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Dissing","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Center for Healthy Aging, Panum Institute, University of Copenhagen, Copenhagen 2200N, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihai","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1024"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05249"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823562"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.810891"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00063-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.242"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/74725"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042760"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200504213521619"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068185"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068191"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.259re1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.3154"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.038"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2524"},{"key":"e_1_3_3_16_2","first-page":"166","article-title":"Cancer associated retinopathy (CAR). 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