{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:35:21Z","timestamp":1792377321301,"version":"4.4.0"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,3,23]]},"abstract":"<jats:p>\n                    The intrinsic role of endogenous IL-17A in spontaneous intestinal tumorigenesis has not been addressed previously to our knowledge. Ablation of IL-17A significantly reduced tumor development in mice bearing a heterozygote mutation in the adenomatous polyposis coli (APC) gene (Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice). There was also a decrease in inflammatory cytokines and proinflammatory mediators, reduced infiltration of lymphocytes including T cells, and preservation of intestinal architecture and the presence of APC protein in intestinal epithelial cells. Interestingly, IL-17A ablation also corrected immunological abnormalities such as splenomegaly and thymic atrophy in Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice. CD4 T cells from Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice showed hyperproliferative potential in vitro and in vivo and increased levels of IL-17A and IL-10. The effector CD4 T cells from Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice were more resistant to regulatory T cell\u2013mediated suppression. Finally, these CD4 T cells induced colitis in immunodeficient mice upon adoptive transfer, whereas the ablation of IL-17A in CD4 T cells in Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice completely abolished this pathogenic potential in vivo. Taken together, our results show that CD4 T cell\u2013derived IL-17A promotes spontaneous intestinal tumorigenesis with altered functions of CD4 T cells in Apc\n                    <jats:sup>Min\/+<\/jats:sup>\n                    mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0912675107","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T00:29:02Z","timestamp":1268094542000},"page":"5540-5544","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":223,"title":["Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis"],"prefix":"10.1073","volume":"107","author":[{"given":"Wook-Jin","family":"Chae","sequence":"first","affiliation":[{"name":"Departments of aImmunobiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Departments of aImmunobiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zelterman","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Hao","sequence":"additional","affiliation":[{"name":"Pathology, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Henegariu","sequence":"additional","affiliation":[{"name":"Departments of aImmunobiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L. M.","family":"Bothwell","sequence":"additional","affiliation":[{"name":"Departments of aImmunobiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,3,8]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00703.x"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.018"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20894"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07240"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080218"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1736"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210059"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1350108"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03485"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00716.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35382"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3445"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3104"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0707"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00477.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.014"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140488"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705268104"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00716.2007"},{"key":"e_1_3_3_24_2","first-page":"6367","article-title":"Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min\/+) mice","volume":"62","author":"Yamada Y","year":"2002","unstructured":"Y Yamada, et al., Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min\/+) mice. Cancer Res 62, 6367\u20136370 (2002).","journal-title":"Cancer Res"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.115"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0912675107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T18:37:08Z","timestamp":1649788628000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0912675107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,8]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,3,23]]}},"alternative-id":["10.1073\/pnas.0912675107"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0912675107","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,8]]},"assertion":[{"value":"2010-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}