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Like glaucoma, susceptibility to transport deficits increases with age and is not necessarily associated with elevated ocular pressure. Transport deficits progress distal-to-proximal, appearing in the colliculus first followed by more proximal secondary targets and then the optic tract. Transport persists through the optic nerve head before finally failing in the retina. Although axon degeneration also progresses distal-to-proximal, myelinated RGC axons and their presynaptic terminals persist in the colliculus well after transport fails. Thus, distal transport loss is predegenerative and may represent a therapeutic target.<\/jats:p>","DOI":"10.1073\/pnas.0913141107","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T23:55:41Z","timestamp":1267487741000},"page":"5196-5201","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":301,"title":["Distal axonopathy with structural persistence in glaucomatous neurodegeneration"],"prefix":"10.1073","volume":"107","author":[{"given":"Samuel D.","family":"Crish","sequence":"first","affiliation":[{"name":"The Vanderbilt Eye Institute and Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Sappington","sequence":"additional","affiliation":[{"name":"The Vanderbilt Eye Institute and Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Inman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Washington, Seattle, WA 98104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Horner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Washington, Seattle, WA 98104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Calkins","sequence":"additional","affiliation":[{"name":"The Vanderbilt Eye Institute and Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00014-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3129\/can j ophthalmol.i07-036"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_3_3_5_2","first-page":"764","article-title":"Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma","volume":"41","author":"Pease ME","year":"2000","unstructured":"ME Pease, SJ McKinnon, HA Quigley, LA Kerrigan-Baumrind, DJ Zack, Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. 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