{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:40:23Z","timestamp":1790221223241,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,1,12]]},"abstract":"<jats:p>Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic herpesviruses that cause various nervous system diseases. Similar to other enveloped viruses, membrane fusion is an essential process for viral entry. Therefore, identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH\/gL. VZV preferentially infected MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues.<\/jats:p>","DOI":"10.1073\/pnas.0913351107","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T21:09:29Z","timestamp":1261516169000},"page":"866-871","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":157,"title":["Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses"],"prefix":"10.1073","volume":"107","author":[{"given":"Tadahiro","family":"Suenaga","sequence":"first","affiliation":[{"name":"Department of Immunochemistry, Research Institute for Microbial Diseases and"},{"name":"WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Immunochemistry, Research Institute for Microbial Diseases and"},{"name":"WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranee","family":"Somboonthum","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Vaccinology, Department of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Mori","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Vaccinology, Department of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan;"},{"name":"Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Arase","sequence":"additional","affiliation":[{"name":"Department of Immunochemistry, Research Institute for Microbial Diseases and"},{"name":"WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan;"},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1086\/522129"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70267-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00233-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.007"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2434"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.377"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.10.4264-4276.1989"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3546"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1050"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/329301a0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1556"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00913-08"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8279-8288.1997"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.1.323-340.2001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.19.9483-9492.2001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.08.046"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.01.023"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00389.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.043"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00400-09"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00867"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114362"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073031"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1161151"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.422"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9530"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0304"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/j.1471-4159.2006.04319.x","article-title":"Myelin-associated glycoprotein (MAG): past, present and beyond","volume":"100","author":"Quarles RH","year":"2007","unstructured":"RH Quarles, Myelin-associated glycoprotein (MAG): past, present and beyond. 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