{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:49:19Z","timestamp":1792666159348,"version":"4.5.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,3,2]]},"abstract":"<jats:p>\n                    A systematic functional analysis across much of the conventional\n                    <jats:italic>Anopheles gambiae<\/jats:italic>\n                    odorant receptor (AgOR) repertoire was carried out in\n                    <jats:italic>Xenopus<\/jats:italic>\n                    oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of\n                    <jats:italic>An. gambiae<\/jats:italic>\n                    that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0913392107","type":"journal-article","created":{"date-parts":[[2010,2,16]],"date-time":"2010-02-16T23:49:50Z","timestamp":1266364190000},"page":"4418-4423","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":377,"title":["Molecular basis of odor coding in the malaria vector mosquito\n                    <i>Anopheles gambiae<\/i>"],"prefix":"10.1073","volume":"107","author":[{"given":"Guirong","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, TN 37235; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison F.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence J.","family":"Zwiebel","sequence":"additional","affiliation":[{"name":"Departments of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, TN 37235; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,2,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03342"},{"key":"e_1_3_3_2_2","volume-title":"Roll Back Malaria Fact Sheet","author":"WHO","year":"2003","unstructured":"; WHO Roll Back Malaria Fact Sheet (World Health Organization, Geneva, 2003)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.44.1.131"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269-283X.2004.00534.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.019"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040020"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076196"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06850"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06861"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.050"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.07.062"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801007105"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81716-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151103998"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055096"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/36.2.158"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005475422978"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2915.2000.00238.x"},{"key":"e_1_3_3_21_2","first-page":"186","article-title":"Chemical analysis of human skin emanations: Comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae)","volume":"18","author":"Bernier UR","year":"2002","unstructured":"UR Bernier, DL Kline, CE Schreck, RA Yost, DR Barnard, Chemical analysis of human skin emanations: Comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae). 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