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Most hair bundles are mechanically coupled by overlying gelatinous structures. Here, we assayed the effects of mechanical coupling on the hair-bundle amplifier by combining dynamic force clamp of a hair bundle from the bullfrog\u2019s saccule with real-time stochastic simulations of hair-bundle mechanics. This setup couples the hair bundle to two virtual hair bundles, called cyber clones, and mimics a situation in which the hair bundle is elastically linked to two neighbors with similar characteristics. We found that coupling increased the coherence of spontaneous hair-bundle oscillations. By effectively reducing noise, the synergic interplay between the hair bundle and its cyber clones also enhanced amplification of sinusoidal stimuli. All observed effects of coupling were in quantitative agreement with simulations. We argue that the auditory amplifier relies on hair-bundle cooperation to overcome intrinsic noise limitations and achieve high sensitivity and sharp frequency selectivity.<\/jats:p>","DOI":"10.1073\/pnas.0913657107","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T23:40:15Z","timestamp":1271720415000},"page":"8079-8084","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification"],"prefix":"10.1073","volume":"107","author":[{"given":"J\u00e9r\u00e9mie","family":"Barral","sequence":"first","affiliation":[{"name":"Laboratoire Physico-Chimie Curie, Centre National de la Recherche Scientifique, Institut Curie, Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Dierkes","sequence":"additional","affiliation":[{"name":"Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lindner","sequence":"additional","affiliation":[{"name":"Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"J\u00fclicher","sequence":"additional","affiliation":[{"name":"Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Martin","sequence":"additional","affiliation":[{"name":"Laboratoire Physico-Chimie Curie, Centre National de la Recherche Scientifique, Institut Curie, Universit\u00e9 Pierre et Marie Curie, 75005 Paris, France; 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