{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:58:30Z","timestamp":1790247510545,"version":"4.1.0"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,5,18]]},"abstract":"<jats:p>\n                    Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common \u03b3 chain (\u03b3\n                    <jats:sub>c<\/jats:sub>\n                    ) are critical for the generation and peripheral homeostasis of naive and memory T cells. Recently, we demonstrated that effector functions fail to develop in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that differentiate in the absence of \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    . To assess the role of \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    cytokines in cell-fate decisions that condition effector versus memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell generation, we compared the response of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    or \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    P14 TCR transgenic mice after challenge with lymphocytic choriomeningitis virus. The intrinsic IL-7-dependent survival defect of \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells was corrected by transgenic expression of human Bcl-2. We demonstrated that although \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    -dependent signals are dispensable for the initial expansion and the acquisition of cytotoxic functions following antigenic stimulation, they condition the terminal proliferation and differentiation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells (i.e., KLRG1\n                    <jats:sup>high<\/jats:sup>\n                    CD127\n                    <jats:sup>low<\/jats:sup>\n                    short-lived effector T cells) via the transcription factor, T-bet. Moreover, the \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    -dependent signals that are critical for memory T cell formation are not rescued by Bcl2 overexpression. Together, these data reveal an unexpected divergence in the requirement for \u03b3\n                    <jats:sub>c<\/jats:sub>\n                    cytokines in the differentiation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    versus CD8\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic T lymphocytes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0913729107","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T22:02:58Z","timestamp":1272924178000},"page":"9311-9316","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":28,"title":["\u03b3\n                    <sub>c<\/sub>\n                    deficiency precludes CD8\n                    <sup>+<\/sup>\n                    T cell memory despite formation of potent T cell effectors"],"prefix":"10.1073","volume":"107","author":[{"given":"H\u00e9l\u00e8ne","family":"Decaluwe","sequence":"first","affiliation":[{"name":"Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U668, Paris F-75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Taillardet","sequence":"additional","affiliation":[{"name":"Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U668, Paris F-75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Corcuff","sequence":"additional","affiliation":[{"name":"Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U668, Paris F-75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Munitic","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine Ren\u00e9 Descartes, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U591, Paris F-75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen K. W.","family":"Law","sequence":"additional","affiliation":[{"name":"Centre d'immunologie Humaine, Institut Pasteur, Paris F-75015, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedita","family":"Rocha","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine Ren\u00e9 Descartes, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U591, Paris F-75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunopathologie Virale, Institut Pasteur, Paris F-75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F-75015, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U668, 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