{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:13:32Z","timestamp":1792019612763,"version":"4.4.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,3,30]]},"abstract":"<jats:p>\n                    Having a parent affected with late-onset Alzheimer's disease (LOAD) is a major risk factor among cognitively normal (NL) individuals. This\n                    <jats:sup>11<\/jats:sup>\n                    C-Pittsburgh Compound B (PiB)-PET study examines whether NL individuals with LOAD parents show increased fibrillar amyloid-beta (A\u03b2) deposition, a hallmark of Alzheimer's disease (AD) pathology and whether there are parent-of-origin effects. Forty-two 50- to 80-year-old NL persons were examined with PiB-PET. These individuals included 14 NL subjects with a maternal family history (FH) of LOAD (FHm), 14 NL subjects with a paternal FH (FHp), and 14 NL subjects with a negative family history of any dementia (FH\u2212). Statistical parametric mapping and automated regions-of-interest were used to compare cerebral-to-cerebellar PiB standardized uptake value ratios, reflecting fibrillar A\u03b2 burden, across groups. FH groups did not differ in age, gender, education, and apolipoprotein E (ApoE) status. NL FHm subjects showed higher PiB retention in AD-affected anterior and posterior cingulate cortex (PCC), precuneus, parietal, temporal, occipital, and frontal cortices, right basal ganglia, and thalamus, compared with FH\u2212 and FHp subjects. FHp subjects showed increased PiB retention in the PCC and frontal cortex, intermediate between FHm and FH\u2212 subjects. Results remained significant after controlling for age, gender, education, and ApoE status. Children of parents with LOAD, particularly those with affected mothers, have increased fibrillar A\u03b2 load in AD-vulnerable regions compared with controls, perhaps accounting for the known increased risk for AD. Present findings may motivate further research on familial transmission and parent-of-origin effects in LOAD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0914141107","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T23:59:34Z","timestamp":1268697574000},"page":"5949-5954","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":116,"title":["Increased fibrillar amyloid-\u03b2 burden in normal individuals with a family history of late-onset Alzheimer\u2019s"],"prefix":"10.1073","volume":"107","author":[{"given":"Lisa","family":"Mosconi","sequence":"first","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha O.","family":"Rinne","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku FIN 20520, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai H.","family":"Tsui","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"},{"name":"Nathan Kline Institute, Orangeburg, NY 10962;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Berti","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"},{"name":"University of Florence, Florence 50134 , Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Murray","sequence":"additional","affiliation":[{"name":"New York University School of Medicine, New York, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora","family":"Scheinin","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku FIN 20520, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"N\u00e5gren","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku FIN 20520, Finland;"},{"name":"PET and Cyclotron Unit, Odense University Hospital, Odense DK-5000, Denmark; 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