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Brain-derived neurotrophic factor (BDNF)-TrkB signaling recruits the Dock3\/WAVE1 complex to the plasma membrane, whereupon Dock3 activates Rac and dissociates from the WAVE complex in a phosphorylation-dependent manner. BDNF induces axonal sprouting through Dock-dependent Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels. Our results highlight a unique mechanism through which Dock-GEFs achieve spatial and temporal restriction of WAVE signaling, and identify Dock-GEF activity as a potential therapeutic target for axonal regeneration.<\/jats:p>","DOI":"10.1073\/pnas.0914514107","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T20:35:31Z","timestamp":1270499731000},"page":"7586-7591","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex"],"prefix":"10.1073","volume":"107","author":[{"given":"Kazuhiko","family":"Namekata","sequence":"first","affiliation":[{"name":"Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Harada","sequence":"additional","affiliation":[{"name":"Department 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