{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:01:13Z","timestamp":1792116073570,"version":"4.4.0"},"reference-count":56,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,4,29]]},"abstract":"<jats:p>\n                    The 1,995,275-bp genome of\n                    <jats:italic>Coxiella burnetii<\/jats:italic>\n                    , Nine Mile phase I RSA493, a highly virulent zoonotic pathogen and category B bioterrorism agent, was sequenced by the random shotgun method. This bacterium is an obligate intracellular acidophile that is highly adapted for life within the eukaryotic phagolysosome. Genome analysis revealed many genes with potential roles in adhesion, invasion, intracellular trafficking, host-cell modulation, and detoxification. A previously uncharacterized 13-member family of ankyrin repeat-containing proteins is implicated in the pathogenesis of this organism. Although the lifestyle and parasitic strategies of\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    resemble that of\n                    <jats:italic>Rickettsiae<\/jats:italic>\n                    and\n                    <jats:italic>Chlamydiae<\/jats:italic>\n                    , their genome architectures differ considerably in terms of presence of mobile elements, extent of genome reduction, metabolic capabilities, and transporter profiles. The presence of 83 pseudogenes displays an ongoing process of gene degradation. Unlike other obligate intracellular bacteria, 32 insertion sequences are found dispersed in the chromosome, indicating some plasticity in the\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    genome. These analyses suggest that the obligate intracellular lifestyle of\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    may be a relatively recent innovation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0931379100","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T12:23:56Z","timestamp":1051619036000},"page":"5455-5460","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":509,"title":["Complete genome sequence of the Q-fever pathogen\n                    <i>Coxiella<\/i>\n                    <i>burnetii<\/i>"],"prefix":"10.1073","volume":"100","author":[{"given":"Rekha","family":"Seshadri","sequence":"first","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road, Atlanta, GA 30333; Department of Medical Microbiology and Immunology, Texas A&amp;M University System Health Science Center, College Station, TX 77843-1114;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road, Atlanta, GA 30333; Department of Medical Microbiology and Immunology, Texas A&amp;M University System Health Science Center, College Station, TX 77843-1114;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Eisen","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road, Atlanta, GA 30333; Department of Medical Microbiology and Immunology, Texas A&amp;M University System Health Science Center, College Station, TX 77843-1114;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Read","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218; Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Viral and Rickettsial Zoonoses Branch, 1600 Clifton Road, Atlanta, GA 30333; Department of Medical Microbiology and Immunology, Texas A&amp;M University System Health Science Center, College Station, TX 77843-1114;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Nelson","sequence":"additional","affiliation":[{"name":"The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; 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