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EKA\/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA\/B or SP. EKC\/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH\n                    <jats:sub>2<\/jats:sub>\n                    , displayed low potency. EKA\/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA\/B could be\n                    <jats:italic>the<\/jats:italic>\n                    endocrine\/paracrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC\/D.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0931458100","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T14:28:41Z","timestamp":1052836121000},"page":"6245-6250","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":135,"title":["Characterization of the endokinins: Human tachykinins with cardiovascular activity"],"prefix":"10.1073","volume":"100","author":[{"given":"Nigel M.","family":"Page","sequence":"first","affiliation":[{"name":"School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, United Kingdom; Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, United Kingdom; 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