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The dorsal nexus demonstrated dramatically increased depression-associated fMRI connectivity with large portions of each of the three networks. The discovery that these regions are linked together through the dorsal nexus provides a potential mechanism to explain how symptoms of major depression thought to arise in distinct networks\u2014decreased ability to focus on cognitive tasks, rumination, excessive self-focus, increased vigilance, and emotional, visceral, and autonomic dysregulation\u2014could occur concurrently and behave synergistically. It suggests that the newly identified dorsal nexus plays a critical role in depressive symptomatology, in effect \u201chot wiring\u201d networks together; it further suggests that reducing increased connectivity of the dorsal nexus presents a potential therapeutic target.<\/jats:p>","DOI":"10.1073\/pnas.1000446107","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T20:51:16Z","timestamp":1275425476000},"page":"11020-11025","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1104,"title":["Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus"],"prefix":"10.1073","volume":"107","author":[{"given":"Yvette I.","family":"Sheline","sequence":"first","affiliation":[{"name":"Departments of aPsychiatry,"},{"name":"Radiology,"},{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Price","sequence":"additional","affiliation":[{"name":"Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizi","family":"Yan","sequence":"additional","affiliation":[{"name":"Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Mintun","sequence":"additional","affiliation":[{"name":"Departments of aPsychiatry,"},{"name":"Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.05.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.53.100901.135148"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.04.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.048"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004443"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1997.9.5.648"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.041"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812686106"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071043098"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.03.010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm167"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10609"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg HS","year":"1999","unstructured":"HS Mayberg, et al., Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness. 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