{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:24:16Z","timestamp":1781105056371,"version":"3.54.1"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,5,23]]},"abstract":"<jats:p>\n                    Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti-inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10\u2212\/\u2212) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.\n                  <\/jats:p>","DOI":"10.1073\/pnas.100118997","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"6007-6012","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":155,"title":["IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization"],"prefix":"10.1073","volume":"97","author":[{"given":"M. J.","family":"M\u00e4kel\u00e4","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kanehiro","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Borish","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dakhama","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Loader","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Joetham","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Xing","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jordana","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206; and Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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