{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:11:54Z","timestamp":1790356314393,"version":"4.1.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"37","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,9,14]]},"abstract":"<jats:p>\n                    The F-BAR domain containing protein CIP4 (Cdc42 interacting protein 4) interacts with Cdc42 and WASP\/N-WASP and is thought to participate in the assembly of filamentous actin. CIP4\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had normal T- and B-lymphocyte development but impaired T cell-dependent antibody production, IgG antibody affinity maturation, and germinal center (GC) formation, despite an intact CD40L\u2013CD40 axis. CIP4\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice also had impaired contact hypersensitivity (CHS) to haptens, and their T cells failed to adoptively transfer CHS. Ovalbumin-activated CD4\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells from CIP4\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    \/OT-II mice migrated poorly to antigen-challenged skin. Activated CIP4\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    T cells exhibited impaired adhesion and polarization on immobilized VCAM-1 and ICAM-1 and defective arrest and transmigration across murine endothelial cell monolayers under shear flow conditions. These results demonstrate an important role for CIP4 in integrin-dependent T cell-dependent antibody responses and GC formation and in integrin-mediated recruitment of effector T cells to cutaneous sites of antigen-driven immune reactions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1002747107","type":"journal-article","created":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T22:49:18Z","timestamp":1283208558000},"page":"16252-16256","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":27,"title":["Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking"],"prefix":"10.1073","volume":"107","author":[{"given":"Suresh","family":"Koduru","sequence":"first","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel J.","family":"Massaad","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanaswamy","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Le Bras","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko K.","family":"Oyoshi","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Kaku","sequence":"additional","affiliation":[{"name":"Hematology, Children's Hospital, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Hematology, Children's Hospital, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnologia-Consejo Superior de Investigaciones Cientificas, E-28049 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"King","sequence":"additional","affiliation":[{"name":"Departments of dDermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fuhlbrigge","sequence":"additional","affiliation":[{"name":"Divisions of aImmunology and"},{"name":"Departments of dDermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Rodig","sequence":"additional","affiliation":[{"name":"Pathology, Brigham and Women's Hospital, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sage","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Carman","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Alcaide","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Brigham and Women's Hospital, Boston, MA 02115; 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