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However, constitutive AKT activation did not enhance memory CD8 T-cell survival but rather repressed IL-7 and IL-15 receptor expression, STAT5 phosphorylation, and BCL2 expression. Conversely, constitutive STAT5 activation profoundly enhanced effector and memory CD8 T-cell survival and augmented homeostatic proliferation, AKT activation, and BCL2 expression. Taken together, these data illustrate that effector and memory cell viability depends on properly balanced PI3K\/AKT signaling and the maintenance of STAT5 signaling.<\/jats:p>","DOI":"10.1073\/pnas.1003457107","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T22:21:32Z","timestamp":1283898092000},"page":"16601-16606","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":206,"title":["Differential effects of STAT5 and PI3K\/AKT signaling on effector and memory CD8 T-cell survival"],"prefix":"10.1073","volume":"107","author":[{"given":"Timothy W.","family":"Hand","sequence":"first","affiliation":[{"name":"Department of Immunobiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Immunobiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong 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