{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:56:17Z","timestamp":1792079777204,"version":"4.4.0"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,10,19]]},"abstract":"<jats:p>\n                    MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of neural development, including neurogenesis, dendritogenesis, and synapse formation. Rett syndrome (RTT) is a progressive neurodevelopmental disorder caused by mutations in the gene encoding\n                    <jats:italic>methyl-CpG\u2013binding protein 2<\/jats:italic>\n                    (\n                    <jats:italic>MECP2<\/jats:italic>\n                    ). Although Mecp2 is known to act as a global transcriptional regulator, miRNAs that are directly regulated by Mecp2 in the brain are not known. Using massively parallel sequencing methods, we have identified miRNAs whose expression is altered in cerebella of\n                    <jats:italic>Mecp2<\/jats:italic>\n                    -null mice before and after the onset of severe neurological symptoms. In vivo genome-wide analyses indicate that promoter regions of a significant fraction of dysregulated miRNA transcripts, including a large polycistronic cluster of brain-specific miRNAs, are DNA-methylated and are bound directly by Mecp2. Functional analysis demonstrates that the 3\u2032 UTR of messenger RNA encoding\n                    <jats:italic>Brain-derived neurotrophic factor<\/jats:italic>\n                    (\n                    <jats:italic>Bdnf<\/jats:italic>\n                    ) can be targeted by multiple miRNAs aberrantly up-regulated in the absence of Mecp2. Taken together, these results suggest that dysregulation of miRNAs may contribute to RTT pathoetiology and also may provide a valuable resource for further investigations of the role of miRNAs in RTT.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1005595107","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T22:41:48Z","timestamp":1286232108000},"page":"18161-18166","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":152,"title":["Genome-wide analysis reveals methyl-CpG\u2013binding protein 2\u2013dependent regulation of microRNAs in a mouse model of Rett syndrome"],"prefix":"10.1073","volume":"107","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, Intellectual Development and Disabilities Research Center (IDDRC) at The Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research, Republic of Singapore 138672;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Shahab","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research, Republic of Singapore 138672;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Hart","sequence":"additional","affiliation":[{"name":"Rutgers Stem Cell Research Center and"},{"name":"The W. 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Keck Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ 08854;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Ruan","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research, Republic of Singapore 138672;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research, Republic of Singapore 138672;"},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore 117597; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi E.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095;"},{"name":"Department of Psychiatry and Biobehavioral Sciences, Intellectual Development and Disabilities Research Center (IDDRC) at The Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095;"},{"name":"Stem Cell Research Center, Tongji Hospital and School of Medicine, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,10,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir RE","year":"1999","unstructured":"RE Amir, et al., Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23, 185\u2013188 (1999).","journal-title":"Nat Genet"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: From clinic to neurobiology","volume":"56","author":"Chahrour M","year":"2007","unstructured":"M Chahrour, HY Zoghbi, The story of Rett syndrome: From clinic to neurobiology. Neuron 56, 422\u2013437 (2007).","journal-title":"Neuron"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen RZ","year":"2001","unstructured":"RZ Chen, S Akbarian, M Tudor, R Jaenisch, Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27, 327\u2013331 (2001).","journal-title":"Nat Genet"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy J","year":"2001","unstructured":"J Guy, B Hendrich, M Holmes, JE Martin, A Bird, A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27, 322\u2013326 (2001).","journal-title":"Nat Genet"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"12440","DOI":"10.1523\/JNEUROSCI.3321-09.2009","article-title":"Synaptic circuit abnormalities of motor-frontal layer 2\/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency","volume":"29","author":"Wood L","year":"2009","unstructured":"L Wood, NW Gray, Z Zhou, ME Greenberg, GM Shepherd, Synaptic circuit abnormalities of motor-frontal layer 2\/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci 29, 12440\u201312448 (2009).","journal-title":"J Neurosci"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani VS","year":"2005","unstructured":"VS Dani, et al., Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci USA 102, 12560\u201312565 (2005).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuron.2007.08.018","article-title":"MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number","volume":"56","author":"Chao HT","year":"2007","unstructured":"HT Chao, HY Zoghbi, C Rosenmund, MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 56, 58\u201365 (2007).","journal-title":"Neuron"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy J","year":"2007","unstructured":"J Guy, J Gan, J Selfridge, S Cobb, A Bird, Reversal of neurological defects in a mouse model of Rett syndrome. Science 315, 1143\u20131147 (2007).","journal-title":"Science"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/BST0360575","article-title":"The methyl-CpG-binding protein MeCP2 and neurological disease","volume":"36","author":"Bird A","year":"2008","unstructured":"A Bird, The methyl-CpG-binding protein MeCP2 and neurological disease. Biochem Soc Trans 36, 575\u2013583 (2008).","journal-title":"Biochem Soc Trans"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan X","year":"1998","unstructured":"X Nan, et al., Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386\u2013389 (1998).","journal-title":"Nature"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan X","year":"1997","unstructured":"X Nan, FJ Campoy, A Bird, MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88, 471\u2013481 (1997).","journal-title":"Cell"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis JD","year":"1992","unstructured":"JD Lewis, et al., Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905\u2013914 (1992).","journal-title":"Cell"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2010.01.030","article-title":"Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state","volume":"37","author":"Skene PJ","year":"2010","unstructured":"PJ Skene, et al., Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell 37, 457\u2013468 (2010).","journal-title":"Mol Cell"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich K","year":"2003","unstructured":"K Martinowich, et al., DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890\u2013893 (2003).","journal-title":"Science"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen WG","year":"2003","unstructured":"WG Chen, et al., Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885\u2013889 (2003).","journal-title":"Science"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/hmg\/ddp181","article-title":"Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus","volume":"18","author":"Ben-Shachar S","year":"2009","unstructured":"S Ben-Shachar, M Chahrour, C Thaller, CA Shaw, HY Zoghbi, Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus. Hum Mol Genet 18, 2431\u20132442 (2009).","journal-title":"Hum Mol Genet"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour M","year":"2008","unstructured":"M Chahrour, et al., MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320, 1224\u20131229 (2008).","journal-title":"Science"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel DP","year":"2009","unstructured":"DP Bartel, MicroRNAs: Target recognition and regulatory functions. Cell 136, 215\u2013233 (2009).","journal-title":"Cell"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2009.10.020","article-title":"MicroRNAs potentiate neural development","volume":"64","author":"Fineberg SK","year":"2009","unstructured":"SK Fineberg, KS Kosik, BL Davidson, MicroRNAs potentiate neural development. Neuron 64, 303\u2013309 (2009).","journal-title":"Neuron"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","article-title":"A brain-specific microRNA regulates dendritic spine development","volume":"439","author":"Schratt GM","year":"2006","unstructured":"GM Schratt, et al., A brain-specific microRNA regulates dendritic spine development. Nature 439, 283\u2013289 (2006).","journal-title":"Nature"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1073\/pnas.0803072105","article-title":"An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP","volume":"105","author":"Wayman GA","year":"2008","unstructured":"GA Wayman, et al., An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA 105, 9093\u20139098 (2008).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.1116502","article-title":"Sequence variants in SLITRK1 are associated with Tourette's syndrome","volume":"310","author":"Abelson JF","year":"2005","unstructured":"JF Abelson, et al., Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310, 317\u2013320 (2005).","journal-title":"Science"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1140481","article-title":"A MicroRNA feedback circuit in midbrain dopamine neurons","volume":"317","author":"Kim J","year":"2007","unstructured":"J Kim, et al., A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317, 1220\u20131224 (2007).","journal-title":"Science"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"Baek D","year":"2008","unstructured":"D Baek, et al., The impact of microRNAs on protein output. Nature 455, 64\u201371 (2008).","journal-title":"Nature"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"Selbach M","year":"2008","unstructured":"M Selbach, et al., Widespread changes in protein synthesis induced by microRNAs. Nature 455, 58\u201363 (2008).","journal-title":"Nature"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang Q","year":"2006","unstructured":"Q Chang, G Khare, V Dani, S Nelson, R Jaenisch, The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49, 341\u2013348 (2006).","journal-title":"Neuron"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"e7192","DOI":"10.1371\/journal.pone.0007192","article-title":"Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors","volume":"4","author":"Goff LA","year":"2009","unstructured":"LA Goff, et al., Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. PLoS ONE 4, e7192 (2009).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/nn2010","article-title":"Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA","volume":"10","author":"Klein ME","year":"2007","unstructured":"ME Klein, et al., Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci 10, 1513\u20131514 (2007).","journal-title":"Nat Neurosci"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200908151","article-title":"Cross talk between microRNA and epigenetic regulation in adult neurogenesis","volume":"189","author":"Szulwach KE","year":"2010","unstructured":"KE Szulwach, et al., Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol 189, 127\u2013141 (2010).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ng0906-962","article-title":"Testing for association between MeCP2 and the brahma-associated SWI\/SNF chromatin-remodeling complex","volume":"38","author":"Hu K","year":"2006","unstructured":"K Hu, X Nan, A Bird, W Wang, Testing for association between MeCP2 and the brahma-associated SWI\/SNF chromatin-remodeling complex. Nat Genet 38, 962\u2013964, author reply 964\u2013967. (2006).","journal-title":"Nat Genet"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.07.020","article-title":"Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells","volume":"134","author":"Marson A","year":"2008","unstructured":"A Marson, et al., Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134, 521\u2013533 (2008).","journal-title":"Cell"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1101\/gr.2743304","article-title":"A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain","volume":"14","author":"Seitz H","year":"2004","unstructured":"H Seitz, et al., A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res 14, 1741\u20131748 (2004).","journal-title":"Genome Res"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng1233","article-title":"Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12","volume":"35","author":"Lin SP","year":"2003","unstructured":"SP Lin, et al., Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet 35, 97\u2013102 (2003).","journal-title":"Nat Genet"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.devcel.2009.12.017","article-title":"ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain","volume":"18","author":"Kernohan KD","year":"2010","unstructured":"KD Kernohan, et al., ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell 18, 191\u2013202 (2010).","journal-title":"Dev Cell"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol J","year":"2010","unstructured":"J Krol, I Loedige, W Filipowicz, The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 11, 597\u2013610 (2010).","journal-title":"Nat Rev Genet"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis BP","year":"2003","unstructured":"BP Lewis, IH Shih, MW Jones-Rhoades, DP Bartel, CB Burge, Prediction of mammalian microRNA targets. Cell 115, 787\u2013798 (2003).","journal-title":"Cell"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis BP","year":"2005","unstructured":"BP Lewis, CB Burge, DP Bartel, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15\u201320 (2005).","journal-title":"Cell"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1093\/hmg\/ddn201","article-title":"A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex","volume":"17","author":"Mellios N","year":"2008","unstructured":"N Mellios, HS Huang, A Grigorenko, E Rogaev, S Akbarian, A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 17, 3030\u20133042 (2008).","journal-title":"Hum Mol Genet"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/emboj.2009.10","article-title":"Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels","volume":"28","author":"Fiore R","year":"2009","unstructured":"R Fiore, et al., Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J 28, 697\u2013710 (2009).","journal-title":"EMBO J"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou Z","year":"2006","unstructured":"Z Zhou, et al., Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52, 255\u2013269 (2006).","journal-title":"Neuron"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1073\/pnas.0811648106","article-title":"Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function","volume":"106","author":"Tao J","year":"2009","unstructured":"J Tao, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci USA 106, 4882\u20134887 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrn1667","article-title":"From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome","volume":"6","author":"Bagni C","year":"2005","unstructured":"C Bagni, WT Greenough, From mRNP trafficking to spine dysmorphogenesis: The roots of fragile X syndrome. Nat Rev Neurosci 6, 376\u2013387 (2005).","journal-title":"Nat Rev Neurosci"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ncb1876","article-title":"A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis","volume":"11","author":"Siegel G","year":"2009","unstructured":"G Siegel, et al., A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol 11, 705\u2013716 (2009).","journal-title":"Nat Cell Biol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/BJ20100024","article-title":"Regulation of the miR-212\/132 locus by MSK1 and CREB in response to neurotrophins","volume":"428","author":"Remenyi J","year":"2010","unstructured":"J Remenyi, et al., Regulation of the miR-212\/132 locus by MSK1 and CREB in response to neurotrophins. Biochem J 428, 281\u2013291 (2010).","journal-title":"Biochem J"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nn.2615","article-title":"MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212","volume":"13","author":"Im HI","year":"2010","unstructured":"HI Im, JA Hollander, P Bali, PJ Kenny, MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nat Neurosci 13, 1120\u20131127 (2010).","journal-title":"Nat Neurosci"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.1190485","article-title":"Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes","volume":"329","author":"Wu H","year":"2010","unstructured":"H Wu, et al., Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science 329, 444\u2013448 (2010).","journal-title":"Science"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.1097434","article-title":"MicroRNA-directed cleavage of HOXB8 mRNA","volume":"304","author":"Yekta S","year":"2004","unstructured":"S Yekta, IH Shih, DP Bartel, MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594\u2013596 (2004).","journal-title":"Science"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1005595107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T03:01:31Z","timestamp":1654570891000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1005595107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,4]]},"references-count":47,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2010,10,19]]}},"alternative-id":["10.1073\/pnas.1005595107"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1005595107","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,4]]},"assertion":[{"value":"2010-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}