{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:26:39Z","timestamp":1792715199573,"version":"4.5.0"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"23","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,6,8]]},"abstract":"<jats:p>\n                    Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O\n                    <jats:sub>2<\/jats:sub>\n                    sensing by the carotid body, a sensory organ that monitors arterial blood O\n                    <jats:sub>2<\/jats:sub>\n                    levels and stimulates breathing in response to hypoxia. We now show that hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is a physiologic gasotransmitter of the carotid body, enhancing its sensory response to hypoxia. Glomus cells, the site of O\n                    <jats:sub>2<\/jats:sub>\n                    sensing in the carotid body, express cystathionine \u03b3-lyase (CSE), an H\n                    <jats:sub>2<\/jats:sub>\n                    S-generating enzyme, with hypoxia increasing H\n                    <jats:sub>2<\/jats:sub>\n                    S generation in a stimulus-dependent manner. Mice with genetic deletion of CSE display severely impaired carotid body response and ventilatory stimulation to hypoxia, as well as a loss of hypoxia-evoked H\n                    <jats:sub>2<\/jats:sub>\n                    S generation. Pharmacologic inhibition of CSE elicits a similar phenotype in mice and rats. Hypoxia-evoked H\n                    <jats:sub>2<\/jats:sub>\n                    S generation in the carotid body seems to require interaction of CSE with hemeoxygenase-2, which generates carbon monoxide. CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1005866107","type":"journal-article","created":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T23:59:42Z","timestamp":1274745582000},"page":"10719-10724","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":342,"title":["H\n                    <sub>2<\/sub>\n                    S mediates O\n                    <sub>2<\/sub>\n                    sensing in the carotid body"],"prefix":"10.1073","volume":"107","author":[{"given":"Ying-Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasri","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Raghuraman","sequence":"additional","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dangjai","family":"Souvannakitti","sequence":"additional","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moataz M.","family":"Gadalla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh K.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon H.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences,"},{"name":"Solomon H. Snyder Department of Neuroscience; and"},{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanduri R.","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Center for Systems Biology for O2 sensing, Department of Medicine, University of Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90132-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1994"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105010"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00019-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.795"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.268re2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06580.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022634199"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10199"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00799a053"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00630a026"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2926"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199302000-00021"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00036.2009"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021876"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(01)00335-X"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.13.8222"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.3.1636"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.4.1449"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-2259-2_7"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2296"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00644.2007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00807.2007"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.036434"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.14.1829"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734109100"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114033"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3583fje"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000204184.34946.41"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1005866107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T20:55:20Z","timestamp":1649883320000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1005866107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,24]]},"references-count":33,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2010,6,8]]}},"alternative-id":["10.1073\/pnas.1005866107"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1005866107","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4716956.4605054","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,24]]},"assertion":[{"value":"2010-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}