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We find that a bridge protein composed of the avian viral receptor TVB fused to NRG, along with EnvB-psuedotyped virus, is able to direct infection selectively to ErbB4-expressing inhibitory cortical neurons in vivo. Interestingly, although ErbB4 is expressed in a broad range of cortical inhibitory cell types, NRG-dependent infection is restricted to a more selective subset of inhibitory cell types. These results demonstrate a tool that can be used for further studies of NRG and ErbB receptors in brain circuits and demonstrate the feasibility for further development of related bridge proteins to target gene expression to other specific cell types in complex tissues.<\/jats:p>","DOI":"10.1073\/pnas.1006233107","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T22:21:32Z","timestamp":1283898092000},"page":"16703-16708","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor\u2013ligand bridge protein"],"prefix":"10.1073","volume":"107","author":[{"given":"Jiwon","family":"Choi","sequence":"first","affiliation":[{"name":"Systems Neurobiology Laboratories and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A. 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