{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:53:42Z","timestamp":1791197622340,"version":"4.1.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"33","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,8,17]]},"abstract":"<jats:p>Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.<\/jats:p>","DOI":"10.1073\/pnas.1009412107","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T22:12:54Z","timestamp":1280527974000},"page":"14657-14661","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene"],"prefix":"10.1073","volume":"107","author":[{"given":"Magda","family":"Forsberg","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carl\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Meletis","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie S. Y.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanie","family":"Barnab\u00e9-Heider","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats A. A.","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, SE-171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Aarum","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, SE-171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Fris\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(62)90043-X"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2414846"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09229"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07314"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08797"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90507-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.06.024"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08436"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.023"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.028"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01350"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.428"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210764"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711961105"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth758"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90662-X"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-12-03310.1985"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90148-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.05.012"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0027"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02708"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00235-5"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00798-5"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00263-X"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.055"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404180101"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80956-3"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301936"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065598.46411.EF"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.3652"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.8.2196"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.037"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1009412107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T19:26:13Z","timestamp":1649791573000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1009412107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,30]]},"references-count":34,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2010,8,17]]}},"alternative-id":["10.1073\/pnas.1009412107"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1009412107","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,30]]},"assertion":[{"value":"2010-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}