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In mice with a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets including B1 cells were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring fewer B cells were found, and fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were detected. Upon thymus-dependent immunization, IgG titers were diminished, and antigen-specific plasma cells were absent in the bone marrow, although numbers of antigen-specific splenic plasmablasts were normal. KLF2 plays also a role in determining the identity of follicular B cells, as KLF2-deficient follicular B cells showed calcium responses similar to those of MZ B cells and failed to down-regulate MZ B cell signature genes, such as CD21 and CXCR7.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1012858108","type":"journal-article","created":{"date-parts":[[2010,12,27]],"date-time":"2010-12-27T20:45:14Z","timestamp":1293482714000},"page":"710-715","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":106,"title":["B cell homeostasis and plasma cell homing controlled by Kr\u00fcppel-like factor 2"],"prefix":"10.1073","volume":"108","author":[{"given":"Rebecca","family":"Winkelmann","sequence":"first","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Sandrock","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Porstner","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Mathews","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Hobeika","sequence":"additional","affiliation":[{"name":"Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Department of Molecular Immunology, Faculty of Biology, University of Freiburg and Max-Planck Institute for Immunobiology, D-79108 Freiburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reth","sequence":"additional","affiliation":[{"name":"Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Department of Molecular Immunology, Faculty of Biology, University of Freiburg and Max-Planck Institute for Immunobiology, D-79108 Freiburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6069"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schuh","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Martin","family":"J\u00e4ck","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, D-91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2010,12,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7632"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04882"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.795"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4049\/jimmunol.163.7.3662","article-title":"Expression of the transcription factor lung Kr\u00fcppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo","volume":"163","author":"Schober SL","year":"1999","unstructured":"SL Schober, et al., Expression of the transcription factor lung Kr\u00fcppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. 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