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In the present functional MRI study, we compared the brain activity of CB and SI processing either the spatial or the pitch properties of sounds carrying information in both domains (i.e., the same sounds were used in both tasks), using an adaptive procedure specifically designed to adjust for performance level. In addition to showing a substantial recruitment of the occipital cortex for sound processing in CB, we also demonstrate that auditory\u2013spatial processing mainly recruits the right cuneus and the right middle occipital gyrus, two regions of the dorsal occipital stream known to be involved in visuospatial\/motion processing in SI. Moreover, functional connectivity analyses revealed that these reorganized occipital regions are part of an extensive brain network including regions known to underlie audiovisual spatial abilities (i.e., intraparietal sulcus, superior frontal gyrus). We conclude that some regions of the right dorsal occipital stream do not require visual experience to develop a specialization for the processing of spatial information and to be functionally integrated in a preexisting brain network dedicated to this ability.<\/jats:p>","DOI":"10.1073\/pnas.1013928108","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T22:35:37Z","timestamp":1299018937000},"page":"4435-4440","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":300,"title":["Functional specialization for auditory\u2013spatial processing in the occipital cortex of congenitally blind humans"],"prefix":"10.1073","volume":"108","author":[{"given":"Olivier","family":"Collignon","sequence":"first","affiliation":[{"name":"Centre de Recherche en Neuropsychologie et Cognition, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3C 3J7;"},{"name":"Centre de Recherches, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada H3T 1C5; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Vandewalle","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuroimagerie Fonctionnelle, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montreal, QC, Canada H3W 1W5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Voss","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neuropsychologie et Cognition, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3C 3J7;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Albouy","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuroimagerie Fonctionnelle, Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montreal, QC, Canada H3W 1W5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neuropsychologie et Cognition, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3C 3J7;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lassonde","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neuropsychologie et Cognition, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3C 3J7;"},{"name":"Centre de Recherches, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada H3T 1C5; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Lepore","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neuropsychologie et Cognition, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3C 3J7;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,2,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93948-W"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn848"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144220"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.012"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1669-07.2007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01504-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00983.2009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/hbm.20966","article-title":"Working memory for vibrotactile frequencies: Comparison of cortical activity in blind and sighted individuals","volume":"31","author":"Burton H","year":"2010","unstructured":"H Burton, RJ Sinclair, S Dixit, Working memory for vibrotactile frequencies: Comparison of cortical activity in blind and sighted individuals. 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