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Furthermore, flotillins are essential for NPC1L1-mediated cellular cholesterol uptake, biliary cholesterol reabsorption, and the regulation of lipid levels in mice. Together with NPC1L1, they form cholesterol-enriched membrane microdomains, which function as carriers for bulk of cholesterol. The hypocholesterolemic drug ezetimibe disrupts the association between NPC1L1 and flotillins, which blocks the formation of the cholesterol-enriched microdomains. Our findings reveal a functional role of flotillins in NPC1L1-mediated cholesterol uptake and elucidate the formation of NPC1L1\u2013flotillins-postive cholesterol-enriched membrane microdomains as a mechanism for efficient cholesterol absorption.<\/jats:p>","DOI":"10.1073\/pnas.1014434108","type":"journal-article","created":{"date-parts":[[2010,12,27]],"date-time":"2010-12-27T20:45:14Z","timestamp":1293482714000},"page":"551-556","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":151,"title":["Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake"],"prefix":"10.1073","volume":"108","author":[{"given":"Liang","family":"Ge","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, 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