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To study the role of individual activating Fc\u03b3Rs for IgG subclass activity, we generated an Fc\u03b3RIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.<\/jats:p>","DOI":"10.1073\/pnas.1014515107","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:46:40Z","timestamp":1288054000000},"page":"19396-19401","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":198,"title":["Fc\u03b3RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo"],"prefix":"10.1073","volume":"107","author":[{"given":"Falk","family":"Nimmerjahn","sequence":"first","affiliation":[{"name":"Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lux","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Woigk","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Genetics, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Erlangen-Nuremberg, Nikolaus-Fiebiger-Center, 91054 Erlangen, Germany; 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