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To explore the potential of the trioxacarcins for the development of small-molecule drugs and probes, we have designed a synthetic strategy toward the trioxacarcin scaffold that enables access to both the natural trioxacarcins and nonnatural structural variants. Here, we report a synthetic route to DC-45-A2 from a differentially protected precursor, which in turn is assembled in just six steps from three components of similar structural complexity. The brevity of the sequence arises from strict adherence to a plan in which strategic bond-pair constructions are staged at or near the end of the synthetic route.<\/jats:p>","DOI":"10.1073\/pnas.1015257108","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:04:46Z","timestamp":1295395486000},"page":"6709-6714","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["A multiply convergent platform for the synthesis of trioxacarcins"],"prefix":"10.1073","volume":"108","author":[{"given":"Jakub","family":"\u0160venda","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,1,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.7164\/antibiotics.34.1519","article-title":"Trioxacarcins, novel antitumor antibiotics I. 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