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This disadvantage may be caused by a defect in survival, because RTEs may transduce homeostatic signals inefficiently, and their ability to survive is enhanced with increased expression of IL-7 receptor or B-cell lymphoma 2 (Bcl-2). Conversely, under lymphopenic conditions, enhanced proliferation by RTEs allows them to out-compete their MN T-cell counterparts. These results suggest that in times of need, such as in neonates or lymphopenic adults, RTEs perform well to fill the gaps in the peripheral T-cell pool, but when the periphery already is full, many RTEs are not incorporated into the pool of recirculating lymphocytes.<\/jats:p>","DOI":"10.1073\/pnas.1015286108","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T16:49:42Z","timestamp":1300207782000},"page":"5366-5371","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":66,"title":["Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool"],"prefix":"10.1073","volume":"108","author":[{"suffix":"Jr.","given":"Evan G.","family":"Houston","sequence":"first","affiliation":[{"name":"Department of Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Higdon","sequence":"additional","affiliation":[{"name":"Molecular and Cellular 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