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In response to T cell-independent antigens, KO B cells showed poor secretion of antigen-specific IgM. This deficit led to increased lethality of KO mice after vesicular stomatitis virus infection. KO B cells showed elevated total FOXO transcriptional activity but also increased FOXO1 degradation. Coimmunoprecipitation revealed that endogenous 14-3-3\u03c3 protein formed a complex with FOXO1 protein. Our results suggest that 14-3-3\u03c3 maintains FOXO1 at a consistent level critical for normal B-cell antigen receptor signaling and B-cell survival.<\/jats:p>","DOI":"10.1073\/pnas.1017729108","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T20:45:06Z","timestamp":1294173906000},"page":"1555-1560","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":37,"title":["14-3-3\u03c3 regulates B-cell homeostasis through stabilization of FOXO1"],"prefix":"10.1073","volume":"108","author":[{"given":"Yu-Wen","family":"Su","sequence":"first","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"},{"name":"Department of Immunology Research Center, National Health Research Institute, Zhunan 35053, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyue","family":"Hao","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirao","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"},{"name":"Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa 920-0934, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jye","family":"Lin","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Young","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"},{"name":"Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga 849-8501, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wakeham","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A.","family":"Lang","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Hermeking","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University, D-80337 Munich, Germany; 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