{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:26:43Z","timestamp":1781105203369,"version":"3.54.1"},"reference-count":22,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,7,8]]},"abstract":"\n Injection of neonatal bone marrow cells from mice lacking the gene encoding suppressor of cytokine signaling 1 (SOCS1) into irradiated syngeneic 129\/Sv or C57BL\/6 mice led to a decreased survival, more rapidly occurring in 129\/Sv than in C57BL\/6 mice. Moribund mice did not exhibit the acute or chronic diseases developed by\n Socs1<\/jats:italic>\n -<\/jats:sup>\n \/\n -<\/jats:sup>\n mice but developed a pathology characteristic of graft-versus-host disease with typical chronic inflammatory lesions in the liver, skin, lungs, and gut. The results indicate that cells derived from the\n Socs1<\/jats:italic>\n -<\/jats:sup>\n \/\n -<\/jats:sup>\n bone marrow are autoaggressive but did not identify the cell types involved. Failure of the engrafted\n Socs1<\/jats:italic>\n -<\/jats:sup>\n \/\n -<\/jats:sup>\n marrow cells to reproduce the tissue damage typical of\n Socs1<\/jats:italic>\n -<\/jats:sup>\n \/\n -<\/jats:sup>\n disease indicates that loss of SOCS1 from target tissues may also be required for the development of the\n Socs1<\/jats:italic>\n -\/-<\/jats:sup>\n diseases, such as fatty degeneration of the liver, polymyositis, or corneal inflammation.\n <\/jats:p>","DOI":"10.1073\/pnas.1032925100","type":"journal-article","created":{"date-parts":[[2003,7,8]],"date-time":"2003-07-08T15:18:15Z","timestamp":1057677495000},"page":"8436-8441","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["The lethal effects of transplantation of\n Socs1<\/i>\n -\/-<\/sup>\n bone marrow cells into irradiated adult syngeneic recipients"],"prefix":"10.1073","volume":"100","author":[{"given":"Donald","family":"Metcalf","sequence":"first","affiliation":[{"name":"Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mifsud","sequence":"additional","affiliation":[{"name":"Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladina","family":"Di Rago","sequence":"additional","affiliation":[{"name":"Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren S.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,6,23]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-5-378"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14395"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80048-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01294.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80047-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160255197"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00132-7"},{"key":"e_1_3_2_8_2","first-page":"1651","volume":"120","year":"1994","unstructured":"Szabo, P. & Mann, J. 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