{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:51:58Z","timestamp":1791294718309,"version":"4.1.0"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    Mitochondria are essential and highly dynamic organelles, constantly undergoing fusion and fission. We analyzed mitochondrial dynamics during infection with the human bacterial pathogen\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    and show that this infection profoundly alters mitochondrial dynamics by causing transient mitochondrial network fragmentation. Mitochondrial fragmentation is specific to pathogenic\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    , and it is not observed with the nonpathogenic\n                    <jats:italic>Listeria innocua<\/jats:italic>\n                    species or several other intracellular pathogens. Strikingly, the efficiency of\n                    <jats:italic>Listeria<\/jats:italic>\n                    infection is affected in cells where either mitochondrial fusion or fission has been altered by siRNA treatment, highlighting the relevance of mitochondrial dynamics for\n                    <jats:italic>Listeria<\/jats:italic>\n                    infection. We identified the secreted pore-forming toxin listeriolysin O as the bacterial factor mainly responsible for mitochondrial network disruption and mitochondrial function modulation. Together, our results suggest that the transient shutdown of mitochondrial function and dynamics represents a strategy used by\n                    <jats:italic>Listeria<\/jats:italic>\n                    at the onset of infection to interfere with cellular physiology.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1100126108","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T04:03:40Z","timestamp":1297742620000},"page":"3612-3617","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":242,"title":["<i>Listeria monocytogenes<\/i>\n                    transiently alters mitochondrial dynamics during infection"],"prefix":"10.1073","volume":"108","author":[{"given":"Fabrizia","family":"Stavru","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur; U604, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale and"},{"name":"USC2020, Institut National de la Recherche Agronomique, 75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bouillaud","sequence":"additional","affiliation":[{"name":"Institut Cochin,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1016, and"},{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104, Universit\u00e9 Paris Descartes, 75014 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sartori","sequence":"additional","affiliation":[{"name":"Plate-Forme de Microscopie Ultrastructurale, Imagopole, Institut Pasteur, Unit\u00e9 de Recherche Associ\u00e9e 2185; 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ricquier","sequence":"additional","affiliation":[{"name":"Institut Cochin,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1016, and"},{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104, Universit\u00e9 Paris Descartes, 75014 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Institut Pasteur; U604, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale and"},{"name":"USC2020, Institut National de la Recherche Agronomique, 75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,2,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.07.008"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.12.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2275"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.03.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3137"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi270"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003257"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.8.1663"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.5.867"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/79944"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/79936"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211046"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvg150"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.2.351"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.8.2245"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00055-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402107"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.11.019"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02282-05"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.024372"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.02.001"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601533"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.12.007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.16.4325"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.05.009"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.258"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000287"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.043"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.07.009"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.05.005"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3614-3618.2003"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00932.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2359-2361.1996"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01305.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702729104"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08963"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/317262a0"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1990.tb00578.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104638"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312366200"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200802164"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209124"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.10.011"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901346"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2003.10.006"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100218"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.04.003"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.30"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.02.064"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.09.026"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.083782"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.003319"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.03.057"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1100126108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T20:06:11Z","timestamp":1649793971000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1100126108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,14]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1073\/pnas.1100126108"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1100126108","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,14]]},"assertion":[{"value":"2011-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}