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Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg that is dependent on retroviral superantigen (\n                    <jats:italic>sag<\/jats:italic>\n                    ) genes encoded in the mouse genome. Sag-dependent Treg expansion was MHC class II dependent, CD4 independent, and required dendritic cells. Thus, one unique mechanism by which certain infectious agents evade host immune responses may be mediated by endogenous Sag-dependent activation and expansion of Treg.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1100213108","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T04:03:40Z","timestamp":1297742620000},"page":"3677-3682","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":82,"title":["Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens"],"prefix":"10.1073","volume":"108","author":[{"given":"George A.","family":"Punkosdy","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Blain","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah D.","family":"Glass","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712; 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