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Up- and down-regulated genes conserved in the human and mouse models and the biological annotation of their expression profiles included many genes\/terms related to neural development, such as cell proliferation, neuronal migration and differentiation, providing a reliable connection between the two species. Our data indicate that use of the combined rodent and human model systems provides an effective strategy to reveal and analyze gene expression changes inflicted by various physical and chemical environmental exposures during prenatal development. It also can potentially provide insight into the pathogenesis of environmentally caused brain disorders in humans.<\/jats:p>","DOI":"10.1073\/pnas.1100903108","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T22:52:57Z","timestamp":1298415177000},"page":"4212-4217","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":70,"title":["Combined transcriptome analysis of fetal human and mouse cerebral cortex exposed to alcohol"],"prefix":"10.1073","volume":"108","author":[{"given":"Kazue","family":"Hashimoto-Torii","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka Imamura","family":"Kawasawa","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasko","family":"Rakic","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrn2598","article-title":"Prenatal exposure to drugs: Effects on brain development and implications for policy and education","volume":"10","author":"Thompson BL","year":"2009","unstructured":"BL Thompson, P Levitt, GD Stanwood, Prenatal exposure to drugs: Effects on brain development and implications for policy and education. 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Nat Rev Neurosci 8, 427\u2013437 (2007).","journal-title":"Nat Rev Neurosci"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/nen.0b013e3180301c06","article-title":"Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development","volume":"66","author":"Hevner RF","year":"2007","unstructured":"RF Hevner, Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. J Neuropathol Exp Neurol 66, 101\u2013109 (2007).","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/jmg.40.5.305","article-title":"Mowat-Wilson syndrome","volume":"40","author":"Mowat DR","year":"2003","unstructured":"DR Mowat, MJ Wilson, M Goossens, Mowat-Wilson syndrome. 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Genes Dev 22, 2479\u20132484 (2008).","journal-title":"Genes Dev"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2008.09.028","article-title":"Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex","volume":"60","author":"Sessa A","year":"2008","unstructured":"A Sessa, CA Mao, AK Hadjantonakis, WH Klein, V Broccoli, Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron 60, 56\u201369 (2008).","journal-title":"Neuron"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1748-7188-4-7","article-title":"Ranking differentially expressed genes from Affymetrix gene expression data: Methods with reproducibility, sensitivity, and specificity","volume":"4","author":"Kadota K","year":"2009","unstructured":"K Kadota, Y Nakai, K Shimizu, Ranking differentially expressed genes from Affymetrix gene expression data: Methods with reproducibility, sensitivity, and specificity. Algorithms Mol Biol 4, 7 (2009).","journal-title":"Algorithms Mol Biol"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/dvdy.21048","article-title":"Reprogramming of genetic networks during initiation of the fetal alcohol syndrome","volume":"236","author":"Green ML","year":"2007","unstructured":"ML Green, et al., Reprogramming of genetic networks during initiation of the fetal alcohol syndrome. 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