{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:25:34Z","timestamp":1789860334421,"version":"4.0.1"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"32","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,8,9]]},"abstract":"<jats:p>\n                    Several studies have demonstrated an apparent link between positive selection on hematopoietic cells (HCs) and an \u201cinnate\u201d T-cell phenotype. Whereas conventional CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are primarily selected on thymic epithelial cells (TECs) and certain innate T cells are exclusively selected on HCs, MHC class Ib-restricted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells appear to be selected on both TECs and HCs. However, whether TEC- and HC-selected T cells represent distinct lineages or whether the same T-cell precursors have the capacity to be selected on either cell type is unknown. Using an M3-restricted T-cell receptor transgenic mouse model, we demonstrate that not only are MHC class Ib-restricted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells capable of being selected on either cell type but that selecting cell type directly affects the phenotype of the resulting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. M3-restricted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells selected on HCs acquire a more activated phenotype and possess more potent effector functions than those selected on TECs. Additionally, these two developmental pathways are active in the generation of the natural pool of M3-restricted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Our results suggest that these two distinct populations may allow MHC class Ib-restricted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to occupy different immunological niches playing unique roles in immune responses to infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1105118108","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:02:29Z","timestamp":1311638549000},"page":"13241-13246","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1073","volume":"108","author":[{"given":"Hoonsik","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Northwestern University, Chicago, IL 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