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Moreover, the data suggest that the B-cell activation occurs predominantly in splenic extrafollicular plasma cell foci and is regulated by natural killer T (NKT) cells that prevent formation of mature germinal centers. We also find evidence that NKT cells control this type of B-cell activation via cytotoxicity mediated by both the perforin and CD95\/CD178 pathways. Thus, NKT cells regulate innate antibody responses initiated by an inflammatory stimulus, suggesting a general mechanism that regulates B-cell behavior in inflammation and autoreactivity.<\/jats:p>","DOI":"10.1073\/pnas.1107830108","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T01:06:49Z","timestamp":1322874409000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells"],"prefix":"10.1073","volume":"108","author":[{"given":"Sara Lind","family":"Enoksson","sequence":"first","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie K.","family":"Grasset","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00e4ggl\u00f6f","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Gabrielsson","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"McGaha","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2013Section of Nephrology, Immunotherapy Center, Georgia Health Sciences University, Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Scheynius","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute, 171 76 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael C. 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