{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:23:27Z","timestamp":1791339807706,"version":"4.3.1"},"reference-count":61,"publisher":"National Academy of Sciences","issue":"41","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,10,11]]},"abstract":"<jats:p>\n                    Lyn kinase deficient mice represent a well established genetic model of autoimmune\/autoinflammatory disease that resembles systemic lupus erythematosus. We report that IL-10 plays a crucial immunosuppressive role in this model, modulating the inflammatory component of the disease caused by myeloid and T-cell activation. Double-mutant\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic>IL-10<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice manifested severe splenomegaly and lymphadenopathy, dramatically increased proinflammatory cytokine production, and severe tissue inflammation. Single-mutant\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed expansion of IL-10\u2013producing B cells. Interestingly, WT B cells adoptively transferred into\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed increased differentiation into IL-10\u2013producing B cells that assumed a similar phenotype to endogenous\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    IL-10\u2013producing B cells, suggesting that the inflammatory environment present in\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice induces IL-10\u2013producing B-cell differentiation. B cells, but not T or myeloid cells, were the critical source of IL-10 able to reduce inflammation and autoimmunity in double mutant\n                    <jats:italic>lyn<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic>IL-10<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. IL-10 secretion by B cells was also crucial to sustain transcription factor Forkhead Box P3 (Foxp3) expression in regulatory T cells during disease development. These data reveal a dominant immunosuppressive function of B-cell\u2013derived IL-10 in the Lyn-deficient model of autoimmunity, extending our current understanding of the role of IL-10 and IL-10\u2013producing B cells in systemic lupus erythematosus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1107913108","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T02:44:44Z","timestamp":1315881884000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":74,"title":["B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice"],"prefix":"10.1073","volume":"108","author":[{"given":"Patrizia","family":"Scapini","sequence":"first","affiliation":[{"name":"Departments of aLaboratory Medicine and"},{"name":"Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, 37134 Verona, Italy; 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