{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:01:21Z","timestamp":1790971281325,"version":"4.1.0"},"reference-count":64,"publisher":"National Academy of Sciences","issue":"44","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na\n                    <jats:sup>+<\/jats:sup>\n                    ,K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase dysfunction in the pathophysiology of bipolar disorder. Here we show that\n                    <jats:italic>Myshkin<\/jats:italic>\n                    mice carrying an inactivating mutation in the neuron-specific Na\n                    <jats:sup>+<\/jats:sup>\n                    ,K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase \u03b13 subunit display a behavioral profile remarkably similar to bipolar patients in the manic state.\n                    <jats:italic>Myshkin<\/jats:italic>\n                    mice show increased Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in cultured cortical neurons and phospho-activation of extracellular signal regulated kinase (ERK) and Akt in the hippocampus. The mood-stabilizing drugs lithium and valproic acid, specific ERK inhibitor SL327, rostafuroxin, and transgenic expression of a functional Na\n                    <jats:sup>+<\/jats:sup>\n                    ,K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase \u03b13 protein rescue the mania-like phenotype of\n                    <jats:italic>Myshkin<\/jats:italic>\n                    mice. These findings establish\n                    <jats:italic>Myshkin<\/jats:italic>\n                    mice as a unique model of mania, reveal an important role for Na\n                    <jats:sup>+<\/jats:sup>\n                    ,K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase \u03b13 in the control of mania-like behavior, and identify Na\n                    <jats:sup>+<\/jats:sup>\n                    ,K\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase \u03b13, its physiological regulators and downstream signal transduction pathways as putative targets for the design of new antimanic therapies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1108416108","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T01:52:20Z","timestamp":1319507540000},"page":"18144-18149","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":133,"title":["Mania-like behavior induced by genetic dysfunction of the neuron-specific Na\n                    <sup>+<\/sup>\n                    ,K\n                    <sup>+<\/sup>\n                    -ATPase \u03b13 sodium pump"],"prefix":"10.1073","volume":"108","author":[{"given":"Greer S.","family":"Kirshenbaum","sequence":"first","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5;"},{"name":"Institute of Medical Science, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Clapcote","sequence":"additional","affiliation":[{"name":"Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Duffy","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina J.","family":"Jarowek","sequence":"additional","affiliation":[{"name":"Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeni H.","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Eye Research and Pathology Laboratory, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Cortez","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"O. 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