{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:50:02Z","timestamp":1781106602392,"version":"3.54.1"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"27","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,7,5]]},"abstract":"<jats:p>\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where the parasite is thought to replicate exclusively within erythrocytes. Infected individuals can also suffer relapses after several years, from\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    and\n                    <jats:italic>Plasmodium ovale<\/jats:italic>\n                    surviving in hepatocytes.\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    and\n                    <jats:italic>Plasmodium malariae<\/jats:italic>\n                    can also persist after the original bout of infection has apparently cleared in the blood, suggesting that host cells other than erythrocytes (but not hepatocytes) may harbor these blood-stage parasites, thereby assisting their escape from host immunity. Using blood stage transgenic\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    -expressing GFP (PbGFP) to track parasites in host cells, we found that the parasite had a tropism for CD317\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells. Other studies using confocal microscopy, in vitro cultures, and cell transfer studies showed that blood-stage parasites could infect, survive, and replicate within CD317\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells, and that small numbers of these cells released parasites infectious for erythrocytes in vivo. These data have identified a unique survival strategy for blood-stage\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    , which has significant implications for understanding the escape of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    spp. from immune-surveillance and for vaccine development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1108579108","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T01:35:06Z","timestamp":1308620106000},"page":"11205-11210","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Rodent blood-stage\n                    <i>Plasmodium<\/i>\n                    survive in dendritic cells that infect naive mice"],"prefix":"10.1073","volume":"108","author":[{"given":"Michelle N.","family":"Wykes","sequence":"first","affiliation":[{"name":"Queensland Institute of Medical Research, Brisbane, Queensland, Australia 4029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Kay","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Manderson","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Q.","family":"Liu","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Brisbane, Queensland, Australia 4029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Richard","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Brisbane, Queensland, Australia 4029;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiraprapa","family":"Wipasa","sequence":"additional","affiliation":[{"name":"University of Chiang Mai Research Institute for Health Sciences, Chiang Mai 50200, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua H.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Brisbane, Queensland, Australia 4029;"},{"name":"Department of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan City, Hubei, People's Republic of China 430030;"},{"name":"Department of Pathogenic Biology and Immunology, Shihezi University School of Medicine, Shihezi City, Xinjiang, People's Republic of China 832002;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm K.","family":"Jones","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Brisbane, Queensland, Australia 4029;"},{"name":"School of Veterinary Science, University of Queensland, Brisbane, Queensland, Australia 4072;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Janse","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Waters","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Molecular Parasitology and Faculty of Biomedical Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom; 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