{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:22:16Z","timestamp":1791249736019,"version":"4.1.0"},"reference-count":14,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2012,2,28]]},"abstract":"<jats:p>\n                    First insights into the molecular programs orchestrating the progression from neural stem cells to cortical projection neurons are emerging. Loss of the transcriptional regulator Ski has been linked to the human 1p36 deletion syndrome, which includes central nervous system defects. Here, we report critical roles for Ski in the maintenance of the neural stem cell pool and the specification of callosal neurons.\n                    <jats:italic>Ski<\/jats:italic>\n                    -deficient callosal neurons lose their identity and ectopically express the transcription factor Ctip2. The misspecified callosal neurons largely fail to form the corpus callosum and instead redirect their axons toward subcortical targets. We identify the chromatin-remodeling factor Satb2 as a partner of Ski, and show that both proteins are required for transcriptional repression of\n                    <jats:italic>Ctip2<\/jats:italic>\n                    in callosal neurons. We propose a model in which Satb2 recruits Ski to the\n                    <jats:italic>Ctip2<\/jats:italic>\n                    locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex. Our findings establish a central role for Ski\u2013Satb2 interactions in regulating transcriptional mechanisms of callosal neuron specification.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1108718109","type":"journal-article","created":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T01:14:46Z","timestamp":1329268486000},"page":"3546-3551","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons"],"prefix":"10.1073","volume":"109","author":[{"given":"Constanze","family":"Baranek","sequence":"first","affiliation":[{"name":"Institute of Physiology, Department of Biomedicine, University of Basel, CH-4056 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Biomedicine, University of Basel, CH-4056 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neurobiology, Neurocure Cluster of Excellence, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Campus Mitte, D-10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine Gaiser","family":"Bonnon","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Biomedicine, University of Basel, CH-4056 Basel, Switzerland;"},{"name":"Institute of Anatomy and Cell Biology, Albert-Ludwigs-University Freiburg, D-79104 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Britanova","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neurobiology, Neurocure Cluster of Excellence, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Campus Mitte, D-10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Lanshakov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neurobiology, Neurocure Cluster of Excellence, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Campus Mitte, D-10117 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Boukhtouche","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland; 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