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In addition, PlGF induced VEGFR-1 signaling and biological responses in tumor cell lines sensitive to anti-PlGF, but not in refractory tumor cell lines or in endothelial cells. Also, genetic ablation of VEGFR-1 signaling in the host did not affect the efficacy of PlGF blockade. Collectively, these findings suggest that the role of PlGF in tumorigenesis largely consists of promoting autocrine\/paracrine growth of tumor cells expressing a functional VEGFR-1 rather than stimulation of angiogenesis.<\/jats:p>","DOI":"10.1073\/pnas.1109029108","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T05:22:51Z","timestamp":1309238571000},"page":"11590-11595","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy"],"prefix":"10.1073","volume":"108","author":[{"given":"Jenny","family":"Yao","sequence":"first","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Wu","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Kasman","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Vogt","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon","family":"Phan","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masabumi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napoleone","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bais","sequence":"additional","affiliation":[{"name":"Genentech, Inc., South San Francisco, CA 94080; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,6,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2524"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.046"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21865"},{"key":"e_1_3_3_5_2","first-page":"213","article-title":"Flt-1 but not KDR\/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor","volume":"7","author":"Sawano A","year":"1996","unstructured":"A Sawano, T Takahashi, S Yamaguchi, M Aonuma, M Shibuya, Flt-1 but not KDR\/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. 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