{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:03:31Z","timestamp":1791896611199,"version":"4.3.4"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"41","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,10,11]]},"abstract":"<jats:p>\n                    CD1d-restricted invariant NKT (iNKT) cells are a unique lineage of T lymphocytes that regulate both innate and adaptive immunity. The Mediator complex forms the bridge between transcriptional activators and the general transcription machinery. Med1\/TRAP220 (also called DRIP205) is a key component of Mediator that interacts with ligand-bound hormone receptors, such as the vitamin D receptor. Here, we show that T-cell\u2013specific Med1 deficiency results in a specific block in iNKT cell development but the development of conventional \u03b1\u03b2 T cells remains grossly normal. The defect is cell-intrinsic and depends neither on apoptosis, cell-cycle control, nor on CD1d expression of CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    double-positive thymocytes. Surprisingly, ectopic expression of a V\u03b114-J\u03b118 T-cell receptor transgene completely rescues the defect caused by Med1 deficiency. At the molecular level, thymic iNKT cells in Med1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    animals display reduced levels of IL-2R\u03b2 and T-bet expression and could not complete terminal maturation. Thus, Med1 is essential for a complete intrathymic development of iNKT cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1109095108","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T02:26:14Z","timestamp":1317090374000},"page":"17105-17110","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Essential role of Mediator subunit Med1 in invariant natural killer T-cell development"],"prefix":"10.1073","volume":"108","author":[{"given":"Xiaojing","family":"Yue","sequence":"first","affiliation":[{"name":"The Max-Planck-Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany;"},{"name":"University of Freiburg, Faculty of Biology, D-79104 Freiburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Izcue","sequence":"additional","affiliation":[{"name":"The Max-Planck-Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany;"},{"name":"Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, D-79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Borggrefe","sequence":"additional","affiliation":[{"name":"The Max-Planck-Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141711"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.01.014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1841"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00962.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.011"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni710"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408449102"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.5.771"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00076-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711558105"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni837"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908249106"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6650"},{"key":"e_1_3_3_15_2","first-page":"23","article-title":"Role of the mediator complex in nuclear hormone receptor signaling","volume":"156","author":"Belakavadi M","year":"2006","unstructured":"M Belakavadi, JD Fondell, Role of the mediator complex in nuclear hormone receptor signaling. 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