{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:59:54Z","timestamp":1791219594296,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,10,18]]},"abstract":"<jats:p>\n                    Contrary to their reptilian ancestors, which had numerous dental generations, mammals are known to usually develop only two generations of teeth. However, a few mammal species have acquired the ability to continuously replace their dentition by the constant addition of supernumerary teeth moving secondarily toward the front of the jaw. The resulting treadmill-like replacement is thus horizontal, and differs completely from the vertical dental succession of other mammals and their extinct relatives. Despite the developmental implications and prospects regarding the origin of supernumerary teeth, this striking innovation remains poorly documented. Here we report another case of continuous dental replacement in an African rodent,\n                    <jats:italic>Heliophobius argenteocinereus<\/jats:italic>\n                    , which combines this dental system with the progressive eruption of high-crowned teeth. The escalator-like mechanism of\n                    <jats:italic>Heliophobius<\/jats:italic>\n                    constitutes an original adaptation to hyper-chisel tooth digging involving high dental wear. Comparisons between\n                    <jats:italic>Heliophobius<\/jats:italic>\n                    and the few mammals that convergently acquired continuous dental replacement reveal that shared inherited traits, including dental mesial drift, delayed eruption, and supernumerary molars, comprise essential prerequisites to setting up this dental mechanism. Interestingly, these dental traits are present to a lesser extent in humans but are absent in mouse, the usual biological model. Consequently,\n                    <jats:italic>Heliophobius<\/jats:italic>\n                    represents a suitable model to investigate the molecular processes leading to the development of supernumerary teeth in mammals, and the accurate description of these processes could be a significant advance for further applications in humans, such as the regeneration of dental tissues.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1109615108","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T01:31:58Z","timestamp":1318296718000},"page":"17355-17359","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["Continuous dental replacement in a hyper-chisel tooth digging rodent"],"prefix":"10.1073","volume":"108","author":[{"given":"Helder","family":"Gomes Rodrigues","sequence":"first","affiliation":[{"name":"Team \u201cEvo-Devo of Vertebrate Dentition,\u201d Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Unit\u00e9 Mixte de Recherche 5242, Centre National de la Recherche Scientifique, Universit\u00e9 Claude Bernard de Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Marangoni","sequence":"additional","affiliation":[{"name":"Team \u201cEvo-Devo of Vertebrate Dentition,\u201d Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Unit\u00e9 Mixte de Recherche 5242, Centre National de la Recherche Scientifique, Universit\u00e9 Claude Bernard de Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"\u0160umbera","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, University of South Bohemia, \u010cesk\u00e9 Bud\u011bjovice 37005, Czech Republic;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tafforeau","sequence":"additional","affiliation":[{"name":"European Synchrotron Radiation Facility, 38043 Grenoble Cedex, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Wendelen","sequence":"additional","affiliation":[{"name":"Vertebrate Section, Zoology Department, Royal Museum for Central Africa, B-3080 Tervuren, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Viriot","sequence":"additional","affiliation":[{"name":"Team \u201cEvo-Devo of Vertebrate Dentition,\u201d Institut de G\u00e9nomique Fonctionnelle de Lyon, Universit\u00e9 de Lyon, Unit\u00e9 Mixte de Recherche 5242, Centre National de la Recherche Scientifique, Universit\u00e9 Claude Bernard de Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.2992\/0145-9058(2004)36[159:EODRIM]2.0.CO;2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.226"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icm044"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06277"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1988.tb00630.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/mamm.1984.48.1.105"},{"key":"e_1_3_3_7_2","first-page":"151","volume-title":"Kangaroos, Wallabies and Rat-Kangaroos","author":"Sanson GD","year":"1989","unstructured":"GD Sanson, Morphological adaptations of teeth to diets and feeding in the Macropodoidea. Kangaroos, Wallabies and Rat-Kangaroos, eds G Grigg, P Jarman, I Hume (Surrey Beatty & Sons, Sydney), pp. 151\u2013168 (1989)."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102681"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20715"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7209555"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5347(94)90267-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809620106"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905252106"},{"key":"e_1_3_3_14_2","first-page":"1","article-title":"The interrelationships of the New and Old World hystricomorph rodents","volume":"56","author":"Landry SC","year":"1957","unstructured":"SC Landry, The interrelationships of the New and Old World hystricomorph rodents. Univ Calif Publ Zool 56, 1\u2013118 (1957).","journal-title":"Univ Calif Publ Zool"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700509"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200616"},{"key":"e_1_3_3_17_2","first-page":"599","article-title":"Evolution of manatees; a speculative history","volume":"56","author":"Domning DP","year":"1982","unstructured":"DP Domning, Evolution of manatees; a speculative history. J Paleontol 56, 599\u2013619 (1982).","journal-title":"J Paleontol"},{"key":"e_1_3_3_18_2","first-page":"69","article-title":"Ecology of Peradorcas concinna in Arnhem land in the wet and dry season","volume":"13","author":"Sanson GD","year":"1985","unstructured":"GD Sanson, JE Nelson, P Fell, Ecology of Peradorcas concinna in Arnhem land in the wet and dry season. Proc Ecol Soc Aust 13, 69\u201372 (1985).","journal-title":"Proc Ecol Soc Aust"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0310.2008.01604.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-003-0439-y"},{"key":"e_1_3_3_21_2","article-title":"Resource characteristics and foraging adaptations in the silvery mole-rat (Heliophobius argenteocinereus), a solitary Afrotropical bathyergid","author":"\u0160kl\u00edba J","year":"2011","unstructured":"J \u0160kl\u00edba, R \u0160umbera, M Vit\u00e1mv\u00e1s, Resource characteristics and foraging adaptations in the silvery mole-rat (Heliophobius argenteocinereus), a solitary Afrotropical bathyergid. Ecol Res, 10.1007\/s11284-011-0860-1. (2011).","journal-title":"Ecol Res"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.2005.00004.x"},{"key":"e_1_3_3_23_2","volume-title":"Australian Mammals: Biology and Captive Management","author":"Jackson SM","year":"2003","unstructured":"SM Jackson Australian Mammals: Biology and Captive Management (CSIRO, Melbourne, 2003)."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-6-14"},{"key":"e_1_3_3_25_2","first-page":"261","article-title":"Age determination in the Cape mole rat Georychus capensis","volume":"20","author":"Taylor PJ","year":"1985","unstructured":"PJ Taylor, JUM Jarvis, TM Crowe, Age determination in the Cape mole rat Georychus capensis. S Afr J Zool 20, 261\u2013267 (1985).","journal-title":"S Afr J Zool"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00271.x"},{"key":"e_1_3_3_27_2","first-page":"1","article-title":"[East African Miocene rodents I. Early Miocene.]","volume":"1","author":"Lavocat R","year":"1973","unstructured":"R Lavocat, [East African Miocene rodents I. Early Miocene.]. M\u00e9m Trav EPHE Inst Montpellier 1, 1\u2013284, French. (1973).","journal-title":"M\u00e9m Trav EPHE Inst Montpellier"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2008.06.013"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21272"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-0935-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20039"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.21275"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400206"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.05.024"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.033803"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607289103"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v016a01"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00339-006-3507-2"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198793"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910086106"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.1339"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1109615108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T20:47:11Z","timestamp":1649796431000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1109615108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,10]]},"references-count":41,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2011,10,18]]}},"alternative-id":["10.1073\/pnas.1109615108"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1109615108","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,10]]},"assertion":[{"value":"2011-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}