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We found that the main nodes of the default-mode network (medial prefrontal and posterior cingulate cortices) were relatively deactivated in experienced meditators across all meditation types. Furthermore, functional connectivity analysis revealed stronger coupling in experienced meditators between the posterior cingulate, dorsal anterior cingulate, and dorsolateral prefrontal cortices (regions previously implicated in self-monitoring and cognitive control), both at baseline and during meditation. Our findings demonstrate differences in the default-mode network that are consistent with decreased mind-wandering. As such, these provide a unique understanding of possible neural mechanisms of meditation.<\/jats:p>","DOI":"10.1073\/pnas.1112029108","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T20:13:57Z","timestamp":1322165637000},"page":"20254-20259","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1129,"title":["Meditation experience is associated with differences in default mode network activity and connectivity"],"prefix":"10.1073","volume":"108","author":[{"given":"Judson A.","family":"Brewer","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Worhunsky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Psychology, Yale University, New Haven, CT 06510;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Oregon, Eugene, OR 97403; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Psychology, Columbia University, New York, NY 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy","family":"Kober","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,11,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192439"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131295"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900234106"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.688"},{"key":"e_1_3_3_6_2","first-page":"1","volume-title":"The Year in Cognitive Neuroscience 2008","author":"Buckner RL","year":"2008","unstructured":"RL Buckner, JR Andrews-Hanna, DL Schacter, The brain's default network: Anatomy, function, and relevance to disease. 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