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Blockade of this process leads to accumulation of autoreactive CD8 T cells in the liver and breach of tolerance, with the development of autoimmune hepatitis. Cell into cell invasion, or emperipolesis, is a long-observed phenomenon for which a physiological role has not been previously demonstrated. We propose that this \u201csuicidal emperipolesis\u201d is a unique mechanism of autoreactive T-cell deletion, a process critical for the maintenance of tolerance.<\/jats:p>","DOI":"10.1073\/pnas.1112251108","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T23:24:23Z","timestamp":1316561063000},"page":"16735-16740","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":156,"title":["Hepatocyte entry leads to degradation of autoreactive CD8 T cells"],"prefix":"10.1073","volume":"108","author":[{"given":"Volker","family":"Benseler","sequence":"first","affiliation":[{"name":"Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Price Alfred Hospital, University of Sydney, Newtown NSW 2042, Australia;"},{"name":"Department of Surgery, University of Regensburg, 93053 Regensburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Warren","sequence":"additional","affiliation":[{"name":"Centre for Education and Research on Ageing and ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord NSW 2139, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Vo","sequence":"additional","affiliation":[{"name":"Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Price Alfred Hospital, University of Sydney, Newtown NSW 2042, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Holz","sequence":"additional","affiliation":[{"name":"Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Price Alfred Hospital, University of Sydney, Newtown NSW 2042, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szun S.","family":"Tay","sequence":"additional","affiliation":[{"name":"Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Price Alfred Hospital, University of Sydney, Newtown NSW 2042, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Le Couteur","sequence":"additional","affiliation":[{"name":"Centre for Education and Research on Ageing and ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord NSW 2139, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Breen","sequence":"additional","affiliation":[{"name":"Centenary Institute and AW Morrow Gastroenterology and Liver Centre, Royal Price Alfred Hospital, University of Sydney, Newtown NSW 2042, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Allison","sequence":"additional","affiliation":[{"name":"Alavita, Inc., Mountain View, CA 94043; 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