{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:43:53Z","timestamp":1781109833924,"version":"3.54.1"},"reference-count":16,"publisher":"National Academy of Sciences","issue":"41","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2011,10,11]]},"DOI":"10.1073\/pnas.1113321108","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T00:09:41Z","timestamp":1317686981000},"page":"16867-16868","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":6,"title":["Chromatin plasticity and the pathogenesis of Huntington disease"],"prefix":"10.1073","volume":"108","author":[{"given":"Michelle E.","family":"Ehrlich","sequence":"first","affiliation":[{"name":"Departments of Neurology, Pediatrics, and Psychiatry, Alzheimer's Disease Research Center, Mount Sinai School of Medicine and James J. Peters VA Medical Center, New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Gandy","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Pediatrics, and Psychiatry, Alzheimer's Disease Research Center, Mount Sinai School of Medicine and James J. Peters VA Medical Center, New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2011,10,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104409108"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2005.06.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1509"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/475S15a"},{"key":"e_1_3_3_5_2","volume-title":"Emerging Safety Science. Forum on Drug Discovery, Development, and Translation","author":"Robinson S","year":"2008","unstructured":"S Robinson, R Pool, R Giffin Emerging Safety Science. Forum on Drug Discovery, Development, and Translation (National Academies Press, Washington, DC, 2008)."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2514"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e31821c31d8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23623"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25100"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021512"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200905138"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.13.12144"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-3-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06563.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4161\/cam.3.1.7511"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1113321108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:27:02Z","timestamp":1649798822000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1113321108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,3]]},"references-count":16,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2011,10,11]]}},"alternative-id":["10.1073\/pnas.1113321108"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1113321108","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,3]]},"assertion":[{"value":"2011-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}