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Analysis both in vivo and in primary satellite-cell cultures, shows that disruption of N-WASp function does not interfere with the program of skeletal myogenic differentiation, and does not affect myoblast motility, morphogenesis and attachment capacity. N-WASp\u2013deficient myoblasts, however, fail to fuse. Furthermore, our analysis suggests that myoblast fusion requires N-WASp activity in both partners of a fusing myoblast pair. These findings reveal a specific role for N-WASp during mammalian myogenesis. WASp-family elements appear therefore to act as universal mediators of the myogenic cell-cell fusion mechanism underlying formation of functional muscle fibers, in both vertebrate and invertebrate species.<\/jats:p>","DOI":"10.1073\/pnas.1116065109","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T11:40:21Z","timestamp":1340797221000},"page":"11211-11216","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":115,"title":["The actin regulator N-WASp is required for muscle-cell fusion in mice"],"prefix":"10.1073","volume":"109","author":[{"given":"Yael","family":"Gruenbaum-Cohen","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itamar","family":"Harel","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel; 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