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Natural products from edible biomaterial provide a structurally diverse resource to alleviate complex disorders via tailored nutritional intervention. We identified a family of natural products, the amorfrutins, from edible parts of two legumes,\n                    <jats:italic>Glycyrrhiza foetida<\/jats:italic>\n                    and\n                    <jats:italic>Amorpha fruticosa<\/jats:italic>\n                    , as structurally new and powerful antidiabetics with unprecedented effects for a dietary molecule. Amorfrutins bind to and activate PPAR\u03b3, which results in selective gene expression and physiological profiles markedly different from activation by current synthetic PPAR\u03b3 drugs. In diet-induced obese and db\/db mice, amorfrutin treatment strongly improves insulin resistance and other metabolic and inflammatory parameters without concomitant increase of fat storage or other unwanted side effects such as hepatoxicity. These results show that selective PPAR\u03b3-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1116971109","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T01:45:25Z","timestamp":1334627125000},"page":"7257-7262","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":196,"title":["Amorfrutins are potent antidiabetic dietary natural products"],"prefix":"10.1073","volume":"109","author":[{"given":"Christopher","family":"Weidner","sequence":"first","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"},{"name":"Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, Takustrasse 3, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens C.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology and Boyce Thompson Institute, Cornell University, Ithaca, NY 14853;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Freiwald","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Quedenau","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kliem","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabell","family":"Witzke","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitam","family":"Kodelja","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ting","family":"Han","sequence":"additional","affiliation":[{"name":"Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Giegold","sequence":"additional","affiliation":[{"name":"Lead Discovery Center GmbH, Emil-Figge-Strasse 76a, 44227 Dortmund, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Baumann","sequence":"additional","affiliation":[{"name":"Lead Discovery Center GmbH, Emil-Figge-Strasse 76a, 44227 Dortmund, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Klebl","sequence":"additional","affiliation":[{"name":"Lead Discovery Center GmbH, Emil-Figge-Strasse 76a, 44227 Dortmund, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Siems","sequence":"additional","affiliation":[{"name":"AnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"M\u00fcller-Kuhrt","sequence":"additional","affiliation":[{"name":"AnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sch\u00fcrmann","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Sch\u00fcler","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas F. 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