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Expression of WT\n                    <jats:italic>ND4<\/jats:italic>\n                    in cells with the G11778A mutation in\n                    <jats:italic>ND4<\/jats:italic>\n                    led to restoration of defective ATP synthesis. Furthermore, with injection into the rodent eye, human\n                    <jats:italic>ND4<\/jats:italic>\n                    DNA levels in mitochondria reached 80% of its mouse homolog. The construct expressed in most inner retinal neurons, and it also suppressed visual loss and optic atrophy induced by a mutant\n                    <jats:italic>ND4<\/jats:italic>\n                    homolog. The adenoassociated virus cassette accommodates genes of up to \u223c5 kb in length, thus providing a platform for introduction of almost any mitochondrial gene and perhaps even allowing insertion of DNA encompassing large deletions of mtDNA, some associated with aging, into the organelle of adults.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1119577109","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T02:49:27Z","timestamp":1334976567000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":154,"title":["Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber\u2019s hereditary optic neuropathy in a mouse model"],"prefix":"10.1073","volume":"109","author":[{"given":"Hong","family":"Yu","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari D.","family":"Koilkonda","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136; 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