{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:20:06Z","timestamp":1781108406151,"version":"3.54.1"},"reference-count":22,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,5,28]]},"abstract":"<jats:p>\n                    A previously undescribed gene, Saitohin (STH), has been discovered in the intron between exons 9 and 10 of the human\n                    <jats:italic>tau<\/jats:italic>\n                    gene. STH is an intronless gene that encodes a 128-aa protein with no clear homologs. The tissue expression of STH is similar to\n                    <jats:italic>tau<\/jats:italic>\n                    , a gene that is implicated in many neurodegenerative disorders. In humans, a single nucleotide polymorphism that results in an amino acid change (Q7R) has been identified in STH and was used in a case control study. The Q7R polymorphism appears to be over-represented in the homozygous state in late onset Alzheimer's disease subjects.\n                  <\/jats:p>","DOI":"10.1073\/pnas.112194599","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:46:49Z","timestamp":1027680409000},"page":"7751-7756","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["A polymorphic gene nested within an intron of the\n                    <i>tau<\/i>\n                    gene: Implications for Alzheimer's disease"],"prefix":"10.1073","volume":"99","author":[{"given":"Chris","family":"Conrad","sequence":"first","affiliation":[{"name":"Department of Pathology, F526, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia","family":"Vianna","sequence":"additional","affiliation":[{"name":"Department of Pathology, F526, Albert 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