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The expression patterns of  ALL-1-associated tumors, in particular ALLs, involve oncogenes, tumor  suppressors, antiapoptotic genes, drug-resistance genes, etc., and correlate  with the aggressive nature of the tumors. The genes whose expression  differentiates between ALLs with and without ALL-1 rearrangement were further  divided into several groups, enabling separation of ALL-1-associated ALLs into  two subclasses. One of the groups included 43 genes that exhibited expression  profiles closely linked to ALLs with ALL-1 rearrangements. Further, there were  evident differences between the expression profiles of AMLs in which ALL-1 had  undergone fusion to other genes and AMLs with partial duplication of ALL-1.  The extensive analysis described here pinpointed genes that might have a  direct role in pathogenesis.<\/jats:p>","DOI":"10.1073\/pnas.1132115100","type":"journal-article","created":{"date-parts":[[2003,6,24]],"date-time":"2003-06-24T13:47:39Z","timestamp":1056462459000},"page":"7853-7858","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Expression profiles of acute lymphoblastic and myeloblastic leukemias  with ALL-1 rearrangements"],"prefix":"10.1073","volume":"100","author":[{"given":"T.","family":"Rozovskaia","sequence":"first","affiliation":[{"name":"Departments of Molecular Cell Biology,  Physics of Complex Systems, and  Immunology, Weizmann Institute of Science, Rehovot  76100, Israel; Kimmel Cancer Center, Jefferson  Medical College, Philadelphia, PA 19107; Institute of  Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia;  Quark Biotech, Inc., Cleveland, OH 44106;  Sheba Medical Center, Tel-Hashomer 52621, Israel; 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