{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:05:37Z","timestamp":1791644737188,"version":"4.3.4"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2012,2,28]]},"abstract":"<jats:p>\n                    When animals are infected with helminthic parasites, resistant hosts show type II helper T immune responses to expel worms. Recently, natural helper (NH) cells or nuocytes, newly identified type II innate lymphoid cells, are shown to express ST2 (IL-33 receptor) and produce IL-5 and IL-13 when stimulated with IL-33. Here we show the relevant roles of endogenous IL-33 for\n                    <jats:italic>Strongyloides venezuelensis<\/jats:italic>\n                    infection-induced lung eosinophilic inflammation by using\n                    <jats:italic>\n                      Il33\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Alveolar epithelial type II cells (ATII) express IL-33 in their nucleus. Infection with\n                    <jats:italic>S. venezuelensis<\/jats:italic>\n                    or intranasal administration of chitin increases in the number of ATII cells and the level of IL-33.\n                    <jats:italic>S. venezuelensis<\/jats:italic>\n                    infection induces pulmonary accumulation of NH cells, which, after being stimulated with IL-33, proliferate and produce IL-5 and IL-13. Furthermore,\n                    <jats:italic>S. venezuelensis<\/jats:italic>\n                    infected\n                    <jats:italic>\n                      Rag2\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice increase the number of ATII cells, NH cells, and eosinophils and the expression of IL-33 in their lungs. Finally, IL-33\u2013stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1201042109","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T00:11:40Z","timestamp":1329178300000},"page":"3451-3456","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":295,"title":["Contribution of IL-33\u2013activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice"],"prefix":"10.1073","volume":"109","author":[{"given":"Koubun","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Immunology and Medical Zoology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichiro","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsukata","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Laboratory of Host defense, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizue","family":"Futatsugi-Yumikura","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology,"},{"name":"Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken J.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Laboratory of Host defense, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan; and"},{"name":"Laboratory 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